Hazard prediction and relevance of laboratory-scale studies
Persoone, G. (1988). Hazard prediction and relevance of laboratory-scale studies, in: Newman, P.J. et al. (Ed.) Environmental protection of the North Sea: International technical conference, London, 24-27 March 1987. pp. 583-596
In: Newman, P.J.; Agg, A.R. (Ed.) (1988). Environmental protection of the North Sea: International technical conference, London, 24-27 March 1987. Heinemann Professional Publishing: Oxford. ISBN 0-434-91370-7. xxviii, 886 pp., more
Predictive hazard assessment of chemicals, pure, in mixtures, or as wastes, is based on the comparison of exposure to effect concentrations. Experimental determination of no-effect levels can be carried out at various levels of biological organisation: within the organism (suborganismal), on individual species (organismal), or with biological communities (supraorganismal). The difficulty of predictive effect analysis consists of relating endpoints determined at various levels of biological organisation to the impact on structure and/or function impairment of natural ecosystems. Examples are given of effect-extrapolations which have been validated at different levels, and which carry promising predictive values.
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