In-vitro biotransformation of chlorinated bornanes (toxaphene) in hepatic microsomes of marine mammals and birds: influence on bioaccumulation and mutagenicity
Boon, J.P.; Helle, M.; Dekker, M.; Sleiderink, H.M.; de Leeuw, J.W.; Klamer, H.J.C.; Govers, B.; Wester, P.; de Boer, J. (1996). In-vitro biotransformation of chlorinated bornanes (toxaphene) in hepatic microsomes of marine mammals and birds: influence on bioaccumulation and mutagenicity. Mém. Mus. natl. hist. nat., Sér. A Zool. 162: 1-6
In: Mémoires du Muséum national d'Histoire naturelle. Série A, Zoologie. Editions du Muséum: Paris. ISSN 0078-9747, more
The in-vitro capacity of hepatic microsomal preparations to metabolise toxaphene-derived chlorinated bornanes (CHBs) increased in the order sperm whale < whitebeaked dolphin, albatross << harbour seal. The congeners CHB-26 and CHB50 were persistent to oxidative biotransformation. The NCI mass spectra of a mono- and a tri-hydroxy metabolite of CHB-32, and a mono-hydroxy metabolite of CHB-62 were obtained. The number of peaks in the toxaphene residue in tissues of the same animals was inversely related to the in-vitro biotransformation capacity. In the mutatox assay, toxaphene was sometimes directly mutagenic but metabolism did not appear to increase the mutagenicity.
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