Netamines H-N, tricyclic alkaloids from the marine sponge Biemna laboutei and their antimalarial activity
Gros, E.; Al-Mourabit, A.; Martin, M.-T.; Sorres, J.; Vacelet, J.; Frederich, M.; Aknin, M.; Kashman, Y.; Gauvin-Bialecki, A. (2014). Netamines H-N, tricyclic alkaloids from the marine sponge Biemna laboutei and their antimalarial activity. J. Nat. Prod. 77(4): 818-823. https://dx.doi.org/10.1021/np4009283
In: Journal of Natural Products. American Chemical Society/American Society of Pharmacognosy: Washington DC. ISSN 0163-3864; e-ISSN 1520-6025, meer
Chemical examination of the CH2Cl2–MeOH (1:1) extract of the Madagascar sponge Biemna laboutei resulted in the isolation of seven new tricyclic alkaloids, netamines H–N (1–7), along with the known netamine G and mirabilins A, C, and F. Their structures were elucidated by interpretation of 1D and 2D NMR spectra and HRESIMS data. All compounds were evaluated for their cytotoxicity against KB cells and their antiplasmodial activity. Netamine M (6) was found to be cytotoxic, with an IC50 value in the micromolar range, and netamine K (4) exhibited activity against Plasmodium falciparum with an IC50 value of 2.4 μM.
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