Drug assimilation in the tissue of European sea bass (Dicentrarchus labrax) fry delivered orally through bioencapsulation
Gapasin, R.S.J.; Nelis, H.; Chair, M.; Sorgeloos, P. (1996). Drug assimilation in the tissue of European sea bass (Dicentrarchus labrax) fry delivered orally through bioencapsulation. J. Appl. Ichthyol. 12(1): 39-42. https://dx.doi.org/10.1111/j.1439-0426.1996.tb00057.x
In: Journal of Applied Ichthyology = Zeitschrift für angewandte Ichthyologie. Blackwell: Berlin. ISSN 0175-8659; e-ISSN 1439-0426, meer
Assimilation levels of the antibacterials trimethoprim (TMP) and sulfamethoxazole (SMX) in sea bass (Dicentrarchus labrax) fry tissue administered orally were investigated. A 1:5 TMP and SMX combination incorporated in oil emulsion (Selco) at 20% and 40% concentrations (w/w) were bioencapsulated in Artemia (Instar II) nauplii. Chemotherapeutics-loaded ('medicated') nauplii were fed to the sea bass fry and drug concentration in the tissue were analysed by high-performance liquid chromatography (HPLC). Fish fed 40% 'medicated' Artemia assimilated significantly higher levels of chemotherapeutics compared with those fed 20% 'medicated' Artemia . Chemotherapeutics given at 40% reached peak levels (19.3 µg TMP/g DW and 23.31 µg SMX/g DW) within 2h while those at 20% peaked (8.74 µg TMP/g DW and 6.73 µg SMX/g DW) after 5h. TWP persisted in the tissues longer (up to 72h) than SMX (12-16h), suggesting a more efficient uptake and retention of the former and/or faster metabolism and elimination of the latter.
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