Ribbon worms (nemerteans) are marine predators, which capture their prey using a proboscis containing a mixture of toxins which brings on rapid paralysis. We have discovered a novel family of peptides (a-nemertides), of which one causes death in green crabs and targets invertebrate voltage-gated sodium channels at low nanomolar concentrations, suggesting a role as drug lead for novel insecticidal and anti-parasitic agents.
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